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Interactions Between Signaling Pathways

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The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...
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Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
08:32

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Published on: March 2, 2014

Virus interactions with human signal transduction pathways.

Zhongming Zhao1, Junfeng Xia, Oznur Tastan

  • 1Departments of Biomedical Informatics, Psychiatry, and Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. zhongming.zhao@vanderbilt.edu

International Journal of Computational Biology and Drug Design
|February 19, 2011
PubMed
Summary

Viruses communicate with human cells using protein-protein interactions (PPIs) that target numerous signaling pathways. Many targeted proteins are known drug targets, offering potential for new antiviral treatments.

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Last Updated: Jun 4, 2026

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13:56

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

Area of Science:

  • Virology
  • Systems Biology
  • Network Medicine

Background:

  • Viruses rely on host cells for their life cycle, necessitating communication via protein-protein interactions (PPIs).
  • Understanding human-virus PPIs is crucial for deciphering viral mechanisms and developing therapeutics.

Purpose of the Study:

  • To investigate how viruses communicate with human hosts by analyzing human-virus PPIs within human signaling pathways.
  • To identify key signaling pathways and proteins targeted by viruses.

Main Methods:

  • Overlaying reported human-virus PPI data onto human signaling pathways from NCI and Reactome databases.
  • Performing pathway enrichment analysis and network analysis to identify central proteins and targeted pathways.

Main Results:

  • 355 out of 671 analyzed human signaling pathways are potentially targeted by at least one virus.
  • Viruses often interact with different proteins depending on the targeted pathway.
  • Hub proteins within merged networks of significant pathways are frequently targeted by viruses.

Conclusions:

  • Viruses extensively target human signaling pathways through PPIs.
  • Central proteins and hub proteins in these pathways are common viral targets.
  • Existing drug targets within virus-targeted pathways represent potential therapeutic strategies against multiple viruses.