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Related Experiment Video

Updated: Jun 4, 2026

Trans-inner Cell Mass Injection of Embryonic Stem Cells Leads to Higher Chimerism Rates

Trans-inner Cell Mass Injection of Embryonic Stem Cells Leads to Higher Chimerism Rates

Published on: May 29, 2018

Production and use of chimeric mice.

J Takaya¹, T Matsusaka, I Ichikawa

¹Division of Nephrology, Vanderbilt University School of Medicine, Nashville, TN.

Methods in Molecular Medicine

|February 19, 2011

Summary

Gene knockout technology precisely inactivates genes to create null-mutant mice. This allows researchers to study gene functions and the effects of gene absence in biological and disease states.

Area of Science:

Genetics
Molecular Biology
Genomics

Background:

Gene targeting enables precise gene modification.
Studying gene function is crucial for understanding biological processes.

Purpose of the Study:

To explain the utility of gene knockout technology.
To highlight the creation of null-mutant mice for functional genomics.

Main Methods:

Gene targeting technology.
Creation of null-mutant mice.
Induction of subtle mutations.

Main Results:

Complete and selective gene inactivation is achievable.
Null-mutant mice models are generated.
Subtle genomic mutations can be induced.

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Intranasal Administration of Recombinant Influenza Vaccines in Chimeric Mouse Models to Study Mucosal Immunity

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Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction

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Conclusions:

Gene knockout is a powerful tool for studying gene function.
This technology aids in understanding gene roles in health and disease.
It facilitates comprehensive genomic analysis.