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Related Experiment Video

Updated: Jun 4, 2026

Isolation of Microvascular Endothelial Tubes from Mouse Resistance Arteries
09:23

Isolation of Microvascular Endothelial Tubes from Mouse Resistance Arteries

Published on: November 25, 2013

Isolated resistance artery preparation.

J P Wesselman1, P H Ratz, R L Prewitt

  • 1Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA.

Methods in Molecular Medicine
|February 19, 2011
PubMed
Summary
This summary is machine-generated.

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Resistance arteries, crucial for regulating blood pressure, adjust their diameter in response to various signals. Understanding these vascular smooth muscle cell responses is key to controlling blood flow.

Area of Science:

  • Physiology
  • Vascular Biology
  • Cardiovascular Research

Background:

  • Resistance arteries (arterioles and small arteries <500 μm) are key regulators of vascular resistance.
  • Vascular tone modulation in these vessels controls lumen diameter and thus blood supply.
  • Smooth muscle and endothelial cells are central to sensing and integrating diverse physiological signals.

Purpose of the Study:

  • To elucidate the mechanisms by which resistance arteries regulate vascular tone.
  • To understand the integration of multiple stimuli by vascular cells.
  • To provide insights into the control of blood flow and blood pressure.

Main Methods:

  • Analysis of vascular smooth muscle cell responses.
  • Investigation of endothelial cell signaling pathways.

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Last Updated: Jun 4, 2026

Isolation of Microvascular Endothelial Tubes from Mouse Resistance Arteries
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Isolation of Microvascular Endothelial Tubes from Mouse Resistance Arteries

Published on: November 25, 2013

Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies
12:42

Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies

Published on: July 14, 2018

The ex vivo Isolated Skeletal Microvessel Preparation for Investigation of Vascular Reactivity
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The ex vivo Isolated Skeletal Microvessel Preparation for Investigation of Vascular Reactivity

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  • Studies on the integration of mechanical and chemical stimuli.

    • Main Results:

    • Identified key signaling pathways involved in vascular tone modulation.
    • Demonstrated the sensitivity of vascular cells to various physiological stimuli.
    • Characterized the integrated response of resistance arteries to complex signaling environments.

    Conclusions:

    • Resistance arteries possess sophisticated mechanisms for sensing and responding to stimuli.
    • Cellular integration of signals is critical for precise regulation of vascular resistance.
    • Findings enhance understanding of cardiovascular homeostasis and disease.