Related Experiment Video

Updated: Jun 4, 2026

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

Glucose concentration in the dialysate does not contribute to lipid profiles in patients undergoing CAPD

Zheng Li1, Huang Fengxian

  • 1Department of Nephrology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, PR China. drzhengli2009@126.com

Renal Failure
|February 22, 2011
PubMed

Insights

Patients with end-stage renal disease on continuous ambulatory peritoneal dialysis (CAPD) exhibit dyslipidemia. Dialysate glucose concentrations did not correlate with altered lipid profiles in CAPD patients.

Area of Science:

  • Nephrology
  • Clinical Biochemistry
  • Metabolic Disorders

Background:

  • End-stage renal disease (ESRD) frequently leads to dyslipidemia.
  • Dialysis modalities, including hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD), may influence lipid profiles.
  • Understanding dyslipidemia in ESRD patients is crucial for managing cardiovascular risk.

Purpose of the Study:

  • To investigate and compare lipid profiles across different ESRD treatments: nondialytic treatment (NT), HD, and CAPD.
  • To analyze the association between dyslipidemia in CAPD patients and the glucose concentration in dialysate.
  • To identify specific lipid abnormalities in ESRD patients undergoing various treatments.

Main Methods:

  • Lipid profiles (cholesterol, triglycerides, HDL, LDL, Apo-A1, Apo-B, Apo-E) were measured in NT (n=64), HD (n=62), and CAPD (n=180) patients.
  • Data from NT patients were collected post-hospitalization; HD and CAPD samples were taken after 3 months of treatment.
  • Pearson correlation was used to assess the relationship between CAPD patient lipid profiles and dialysate glucose levels.

Main Results:

  • Dyslipidemia was prevalent across all groups: 76.56% in NT, 66.13% in HD, and 72.22% in CAPD patients.
  • CAPD patients showed significantly altered levels of cholesterol, triglycerides, HDL, Apo-A1, and Apo-E compared to NT patients (p < 0.05).
  • No significant correlation was found between dialysate glucose concentrations and lipid profiles in CAPD patients.

Conclusions:

  • Patients undergoing CAPD exhibit significant dyslipidemia.
  • The concentration of glucose in the dialysate does not appear to influence lipid profiles in CAPD patients.
  • Dyslipidemia is a common comorbidity in ESRD patients, irrespective of dialysis modality, necessitating further investigation and management strategies.

More Related Videos

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo10:35

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo

Published on: April 6, 2022

Liquid Chromatography Coupled to Refractive Index or Mass Spectrometric Detection for Metabolite Profiling in Lysate-based Cell-free Systems14:42

Liquid Chromatography Coupled to Refractive Index or Mass Spectrometric Detection for Metabolite Profiling in Lysate-based Cell-free Systems

Published on: September 23, 2021

Related Concept Videos

Dialysis01:15

Dialysis

Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
Peritoneal Dialysis I: Introduction and Procedure01:30

Peritoneal Dialysis I: Introduction and Procedure

Peritoneal dialysis (PD) is a procedure that facilitates the exchange of solutes, waste products, electrolytes, and excess fluid between the blood in the peritoneal capillaries and a dialysis solution introduced into the peritoneal cavity.Principles of Peritoneal Dialysis (PD)Diffusion: Waste products such as urea and electrolytes move from high concentrations in the blood to low concentrations in the dialysate across the peritoneal membrane. This mechanism is driven by the concentration...
Glucose Transporters01:27

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
Glucose Absorption Into the Small Intestine01:26

Glucose Absorption Into the Small Intestine

Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and 'exit' via the...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...