Related Experiment Video
Updated: Jun 4, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Factors associated with asthma severity in children: a case-control study
Ana Paula Mendes1, Linjie Zhang, Sílvio O M Prietsch
1Physical Therapy Course, University of Anhanguera, Rio Grande, Brazil.
Insights
Early childhood asthma is linked to early onset, low paternal education, and low income. Fruit consumption may protect against severe asthma in children.
Area of Science:
- Pediatric Pulmonology
- Epidemiology
- Environmental Health
Background:
- Childhood asthma is a significant public health concern.
- Identifying risk and protective factors for persistent childhood asthma is crucial for effective management.
Purpose of the Study:
- To investigate factors associated with the severity of childhood asthma.
- To identify risk factors for persistent asthma in Brazilian children.
Main Methods:
- A case-control study was conducted with 171 Brazilian children (2-12 years) diagnosed with asthma.
- Children were categorized into persistent asthma (cases) and intermittent asthma (controls).
- Data were collected via parental interviews, and logistic regression was used to assess associations.
Main Results:
- Early disease onset (before 2 years), low paternal education (<9 years), and low household income (≤1 minimum wage) were independent risk factors for persistent asthma.
- Adjusted odds ratios (OR) for these factors were 2.56, 2.49, and 4.36, respectively.
- Regular fruit consumption in the past 30 days showed an inverse association with persistent asthma (adjusted OR: 0.19).
Conclusions:
- Early onset, low paternal education, and low household income are significant risk factors for persistent childhood asthma.
- Regular fruit consumption may act as a protective factor against more severe asthma presentations in children.
- These findings highlight the importance of socioeconomic and dietary factors in childhood asthma severity.
Objective:
To investigate factors associated with the severity of childhood asthma.
Methods:
We conducted a case-control study in a group of Brazilian children (2-12 years old) with diagnosis of asthma attending the pediatric pulmonology clinic of a teaching hospital. The study sample consisted of cases (children with persistent asthma) and controls (children with intermittent asthma). Data were collected through an interview with the child's parent or caretaker using a standard questionnaire. Association between asthma severity and studied variables was assessed by calculating odds ratios (OR) and 95% confidence interval (95% CI) through logistic regression test.
Results:
171 children were included in this study, of which 104 (61%) had persistent asthma and 67 (39%) had intermittent asthma. Onset of the disease before 2 years of age, paternal educational level lower than 9 years, and low household income (≤1 minimum wage per month) were independent risk factors for persistent asthma, with adjusted OR (95% CI) of 2.56 (1.01-6.48), 2.49 (1.04-5.99), and 4.36 (1.06-17.87), respectively. Regular consumption of fruits during the last 30 days was inversely associated with the risk of having persistent asthma, with an adjusted OR (95% CI) of 0.19 (0.04-0.97).
Conclusions:
Early onset of the disease, low paternal education, and low household income are independent risk factors for persistent childhood asthma. Regular consumption of fruits appears to be a protective factor against more severe asthma in children.
Related Concept Videos
Asthma-I: Introduction
Asthma I: Introduction
Asthma-III: Symptoms and Complications
Classification of Asthma
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma III: Clinical Manifestations
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
