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Triggering receptor expressed on myeloid cells (TREM)-1 participates in Schistosoma mansoni inflammatory responses

P-C Cheng1, C-N Lin, Y-J Chen

  • 1Institute of Tropical Medicine, National Yang-Ming University, Taipei, Taiwan.

Parasite Immunology
|February 22, 2011
PubMed

Insights

This study shows triggering receptor expressed on myeloid cells-1 (TREM-1) increases during Schistosoma mansoni infection in mice. However, parasite eggs may suppress TREM-1, potentially reducing the inflammatory response.

Area of Science:

  • Immunology
  • Parasitology
  • Cell Biology

Background:

  • Inflammatory responses are amplified by triggering receptor expressed on myeloid cells-1 (TREM-1).
  • Limited research exists on TREM-1's role in macrophage activation during parasitic infections.

Purpose of the Study:

  • To investigate the role of TREM-1 in the Schistosoma mansoni infection model across early and chronic phases.
  • To analyze TREM-1 expression on myeloid cells and its regulation by parasite components.

Main Methods:

  • Flow cytometry to assess TREM-1 protein expression on CD11b(+) myeloid cells.
  • Real-time PCR to measure TREM-1 mRNA levels in splenic and liver tissues.
  • Stimulation of J774A.1 macrophage cell line with Schistosoma egg antigen.

Main Results:

  • TREM-1 protein and mRNA expression gradually increased in splenic myeloid cells, peaking at 5 weeks post-infection.
  • TREM-1 mRNA expression in liver tissue remained unchanged throughout infection.
  • Schistosoma egg antigen inhibited TREM-1 expression on macrophages.

Conclusions:

  • TREM-1 plays a role in the immune response to Schistosoma mansoni infection.
  • Schistosoma eggs may downregulate TREM-1 expression, modulating the host's inflammatory response.

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