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Influences of cyclopentolate hydrochloride on anterior segment parameters with Pentacam in children

Melis Palamar1, Sait Egrilmez, Onder Uretmen

  • 1Faculty of Medicine, Department of Ophthalmology, Ege University, Izmir, Turkey. melispalamar@hotmail.com

Acta Ophthalmologica
|February 22, 2011
PubMed

Insights

Cyclopentolate hydrochloride 1% eye drops significantly decrease central corneal thickness and increase anterior chamber depth and volume in children. These changes, measured by Pentacam, are important for clinical interpretation.

Area of Science:

  • Ophthalmology
  • Pediatric Ophthalmology
  • Ocular Biometry

Background:

  • Accurate anterior segment measurements are crucial for pediatric eye care.
  • Cycloplegic agents can influence ocular biometric parameters.
  • Understanding these effects is essential for reliable clinical assessments.

Purpose of the Study:

  • To evaluate the impact of cyclopentolate hydrochloride 1% on key anterior segment parameters in children.
  • To compare changes in ocular measurements before and after cycloplegia using Pentacam imaging.
  • To assess the reliability of Pentacam measurements in cyclopleged pediatric eyes.

Main Methods:

  • A prospective study involving 50 children receiving cyclopentolate hydrochloride 1% and a control group of 31 children.
  • Pentacam rotating Scheimpflug camera was used to measure anterior chamber depth (ACD), anterior chamber volume (ACV), and central corneal thickness (CCT).
  • Statistical analysis included paired and unpaired t-tests to compare measurements within and between groups.

Main Results:

  • Cyclopentolate hydrochloride 1% significantly decreased central corneal thickness (CCT).
  • Significant increases were observed in anterior chamber depth (ACD) and anterior chamber volume (ACV) post-instillation.
  • No significant changes in these parameters were noted in the control group over equivalent time intervals.

Conclusions:

  • Cyclopentolate hydrochloride 1% significantly alters CCT, ACD, and ACV in pediatric eyes.
  • These cycloplegia-induced biometric changes necessitate consideration during Pentacam-based clinical interpretations in children.
  • Ophthalmologists should account for these refractive parameter shifts for accurate pediatric eye evaluations.
Abstract

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