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Primary splenic angiosarcoma.

Kamran S Hamid1, Joaquin A Rodriguez, Terry C Lairmore

  • 1The Texas A&M University Health Science Center, 2401 South 31st Street, Temple, Texas 76508, USA. kshamid@medicine.tamhsc.edu

JSLS : Journal of the Society of Laparoendoscopic Surgeons
|February 22, 2011
PubMed
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Primary splenic angiosarcoma is a rare cancer. Early diagnosis and splenectomy offer the best survival chance for this aggressive neoplasm.

Area of Science:

  • Oncology
  • Pathology

Background:

  • Primary splenic angiosarcoma is a rare and aggressive vascular endothelial neoplasm.
  • It often presents with non-specific symptoms, leading to delayed diagnosis.

Observation:

  • A 70-year-old woman presented with dyspnea and chest discomfort due to pleural effusion.
  • Abdominal CT revealed splenic enlargement; thoracentesis suggested malignancy.
  • Laparoscopic splenectomy confirmed primary splenic angiosarcoma.

Findings:

  • The patient developed metastatic disease to the liver and lung after initial chemotherapy.
  • Treatment was switched to Ifosfamide and Doxorubicin.
  • She remains alive with stable disease at 9 months.

Implications:

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  • Primary splenic angiosarcoma has a poor prognosis despite treatment.
  • Prompt splenectomy before rupture is critical for improving survival.
  • Further research into effective therapeutic strategies is warranted.