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Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 
Endoscopic Procedures II: Colonoscopy01:25

Endoscopic Procedures II: Colonoscopy

The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

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Articles linked to this work by shared authors, journal, and citation graph.

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Same author

[The duodenal microbiota composition in children with active coeliac disease is influenced by the degree of enteropathy].

Anales de pediatria (Barcelona, Spain : 2003)·2015
Same author

[D-lactic acidosis in a ten months old infant with short bowel syndrome: Early suspicion equals early treatment].

Anales de pediatria (Barcelona, Spain : 2003)·2015
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Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease.

Journal of Crohn's & colitis·2014
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[Exclusive enteral nutrition continues to be first line therapy for pediatric Crohn's disease in the era of biologics].

Anales de pediatria (Barcelona, Spain : 2003)·2014
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Oral tacrolimus for pediatric steroid-resistant ulcerative colitis.

Journal of Crohn's & colitis·2013
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[Plasma citrulline as a marker of loss of enterocitary mass in coeliac disease in childhood].

Nutricion hospitalaria·2012

Related Experiment Video

Updated: Jun 4, 2026

Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults
04:14

Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults

Published on: February 28, 2025

[Colectomy in paediatric patients with ulcerative colitis].

C Sierra Salinas1, J Blasco Alonso, V M Navas López

  • 1Unidad de Gastroenterología, Hepatología y Nutrición Infantil, Hospital Materno-Infantil, Málaga, Spain.

Anales De Pediatria (Barcelona, Spain : 2003)
|February 22, 2011
PubMed
Summary

Pediatric Ulcerative Colitis (UC) patients under five years old often require colectomy, regardless of treatment. Urgent colectomy was frequently needed for severe cases unresponsive to steroids and immunomodulators.

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Caudal-to-cranial Approach in Laparoscopic Right Hemicolectomy with Complete Mesocolon Excision and D3 Lymph Node Dissection
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Last Updated: Jun 4, 2026

Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults
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Caudal-to-cranial Approach in Laparoscopic Right Hemicolectomy with Complete Mesocolon Excision and D3 Lymph Node Dissection
06:46

Caudal-to-cranial Approach in Laparoscopic Right Hemicolectomy with Complete Mesocolon Excision and D3 Lymph Node Dissection

Published on: January 9, 2026

Area of Science:

  • Pediatric Gastroenterology
  • Inflammatory Bowel Disease Research
  • Surgical Gastroenterology

Context:

  • Ulcerative Colitis (UC) management in children presents unique challenges.
  • Limited studies address medical treatment failure leading to colectomy in pediatric UC.
  • Colectomy rates in pediatric UC underscore the need for effective early interventions.

Purpose:

  • To analyze colectomy outcomes in pediatric Ulcerative Colitis patients.
  • To identify factors influencing the need for urgent versus elective colectomy.
  • To evaluate the impact of age and treatment on colectomy rates in pediatric UC.

Summary:

  • A retrospective study identified 14 pediatric UC patients (under 14 years) who underwent colectomy due to treatment failure between 1984-2009.
  • Younger children, especially those under five, had a higher likelihood of requiring colectomy, with all such cases occurring within six months of diagnosis.
  • Urgent colectomy was common, often necessitated by a lack of response to potent medical regimens including steroids and immunomodulators like tacrolimus, cyclosporine, or infliximab.

Impact:

  • Age is a critical prognostic factor in pediatric UC, with very young children facing a near-certainty of colectomy.
  • The study highlights the evolution of treatment strategies, noting that elective colectomies were predominantly performed before 1999.
  • Findings emphasize the importance of aggressive early management and the limitations of older treatment protocols in achieving remission for severe pediatric UC.