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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Prodrugs01:30

Prodrugs

Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
Prodrugs help overcome...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...

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Related Experiment Video

Updated: Jun 4, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

Prodrugs for improving tumor targetability and efficiency.

Rubi Mahato1, Wanyi Tai, Kun Cheng

  • 1Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 2464 Charlotte Street, Kansas City, MO 64108, USA.

Advanced Drug Delivery Reviews
|February 22, 2011
PubMed
Summary
This summary is machine-generated.

Targeted prodrugs enhance chemotherapy by improving drug selectivity and reducing toxicity. This approach utilizes tumor-targeting ligands, specific enzyme activation, and advanced delivery systems for more effective cancer treatment.

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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Published on: June 13, 2014

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Last Updated: Jun 4, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Area of Science:

  • Oncology
  • Medicinal Chemistry
  • Drug Delivery

Background:

  • Chemotherapy is a cornerstone of cancer treatment but suffers from non-selectivity and high toxicity.
  • Improving drug selectivity is crucial for enhancing therapeutic efficacy and patient outcomes.
  • Prodrug strategies offer a promising avenue to overcome these limitations.

Purpose of the Study:

  • To review advanced prodrug designs aimed at increasing the selectivity of chemotherapy drugs.
  • To explore strategies for enhancing tumor-specific drug uptake and activation.
  • To highlight innovative approaches for targeted cancer therapy.

Main Methods:

  • Incorporation of tumor-targeting ligands, transporter-associated ligands, and polymers into prodrug structures.
  • Design of prodrugs activated by enzymes overexpressed in tumor microenvironments.
  • Utilizing antibody-enzyme conjugates or gene delivery vectors for targeted enzyme-mediated prodrug activation.

Main Results:

  • Targeted prodrugs demonstrate enhanced tumor accumulation through specific ligand interactions.
  • Enzyme-activated prodrugs achieve selective drug release within cancer cells.
  • These strategies significantly improve the therapeutic index of chemotherapy agents.

Conclusions:

  • Targeted prodrugs represent a significant advancement in chemotherapy, offering improved selectivity and reduced systemic toxicity.
  • Prodrug design incorporating targeting moieties and tumor-specific activation mechanisms holds great potential for future cancer therapeutics.
  • Further research into these advanced prodrug strategies can lead to more effective and safer cancer treatments.