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Updated: Jun 4, 2026

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
Symptom-based diagnostic criteria for irritable bowel syndrome: the more things change, the more they stay the same
Paul Moayyedi1, Alexander C Ford
1Division of Gastroenterology, Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University Medical Centre, 1200 Main Street West, HSC Room 4W8E, Hamilton, ON, L8N 3Z5 Canada. moayyep@mcmaster.ca
Abstract:
Medical students are taught that 90% of all diagnoses are made through careful assessment of the patients' symptoms. Clinicians now rely heavily on techniques such as endoscopy or radiology before making a definitive diagnosis of organic disease. Most gastroenterologists would require endoscopic confirmation before labeling a patient as having peptic ulcer disease and would make a diagnosis of Crohn disease based on small bowel radiology or colonoscopy. However, the most common causes of symptoms of the gastrointestinal tract are functional. It is important that clinicians obtain a thorough history so that the disorder of the patient can be accurately defined.
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