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S100A8/A9 complex as a new biomarker in prediction of mortality in elderly patients with severe heart failure

Li-Ping Ma1, Espen Haugen, Masaki Ikemoto

  • 1Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden. Liping.Ma@wlab.gu.se

International Journal of Cardiology
|February 22, 2011
PubMed

Insights

The S100A8/A9 complex is a valuable biomarker for predicting one-year mortality in elderly patients with chronic heart failure (CHF). Combining it with IL-6 offers enhanced prognostic information for this population.

Area of Science:

  • Cardiology
  • Biomarker Research
  • Inflammation Studies

Background:

  • The S100A8/A9 complex is an inflammation-related protein correlated with C-reactive protein levels.
  • Its specific role in chronic heart failure (CHF) has not been fully elucidated.
  • Understanding novel biomarkers is crucial for managing CHF progression.

Purpose of the Study:

  • To investigate the role of the S100A8/A9 complex as a biomarker in patients with chronic heart failure (CHF).
  • To assess the predictive value of S100A8/A9 complex and other inflammatory markers for mortality in CHF.
  • To evaluate the combined prognostic utility of S100A8/A9 complex with other biomarkers.

Main Methods:

  • Measured circulating levels of S100A8/A9 complex, IL-6, IL-8, TNF-α, and BNP in CHF patients, hypertensive patients without CHF, and healthy controls.
  • Utilized Cox regression analysis to identify predictors of mortality at 6 months, 1 year, and 2 years.
  • Followed patients for up to 1480 days to determine cumulative mortality rates.

Main Results:

  • Plasma levels of S100A8/A9 complex, IL-6, IL-8, and TNF-α were significantly elevated in CHF patients compared to controls.
  • A positive correlation was observed between S100A8/A9 complex and IL-6 and IL-8.
  • S100A8/A9 complex, IL-6, and IL-8 emerged as significant predictors of mortality at various time points, with a combination of S100A8/A9 complex and IL-6 showing powerful predictive value.

Conclusions:

  • The S100A8/A9 complex serves as a useful biomarker for predicting one-year mortality in elderly CHF patients.
  • Combining S100A8/A9 complex with IL-6 provides additive prognostic information.
  • These findings highlight the potential of S100A8/A9 complex in risk stratification for vulnerable heart failure populations.
Abstract

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