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Related Experiment Video

Updated: Jun 4, 2026

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice
09:29

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice

Published on: June 11, 2020

Quantitative EEG analysis in neonatal hypoxic ischaemic encephalopathy.

I Korotchikova1, N J Stevenson, B H Walsh

  • 1Neonatal Brain Research Group, University College Cork, Ireland. I.Korotchikova@ucc.ie

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|February 22, 2011
PubMed
Summary

Quantitative EEG measures correlate with visual grading of hypoxic-ischemic encephalopathy (HIE) in neonates. These findings support developing automated HIE classification systems using qEEG data.

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Area of Science:

  • Neonatal neurology
  • Quantitative electroencephalography (qEEG)
  • Hypoxic-ischemic encephalopathy (HIE)

Background:

  • Hypoxic-ischemic encephalopathy (HIE) is a major cause of neonatal brain injury.
  • Visual interpretation of neonatal electroencephalogram (EEG) is standard for HIE grading.
  • Objective qEEG measures may offer a more standardized approach to HIE assessment.

Purpose of the Study:

  • To investigate the association between qEEG measures and visual HIE grading.
  • To determine if qEEG can predict established EEG/HIE grades.

Main Methods:

  • Continuous video-EEG recorded for up to 72 hours in 54 infants with HIE.
  • EEG segments analyzed and graded by two blinded electroencephalographers.
  • Calculation of various qEEG parameters including power, skewness, kurtosis, amplitude, and discontinuity.

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Amplitude-Integrated EEG in Infants at Risk of Hypoxic-Ischemic Encephalopathy: A Feasibility Study in Road and Air Transport in Western Australia
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Amplitude-Integrated EEG in Infants at Risk of Hypoxic-Ischemic Encephalopathy: A Feasibility Study in Road and Air Transport in Western Australia

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Application of an Amplitude-integrated EEG Monitor (Cerebral Function Monitor) to Neonates
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Application of an Amplitude-integrated EEG Monitor (Cerebral Function Monitor) to Neonates

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Last Updated: Jun 4, 2026

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice
09:29

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice

Published on: June 11, 2020

Amplitude-Integrated EEG in Infants at Risk of Hypoxic-Ischemic Encephalopathy: A Feasibility Study in Road and Air Transport in Western Australia
05:15

Amplitude-Integrated EEG in Infants at Risk of Hypoxic-Ischemic Encephalopathy: A Feasibility Study in Road and Air Transport in Western Australia

Published on: June 21, 2024

Application of an Amplitude-integrated EEG Monitor (Cerebral Function Monitor) to Neonates
05:58

Application of an Amplitude-integrated EEG Monitor (Cerebral Function Monitor) to Neonates

Published on: September 6, 2017

Main Results:

  • Significant differences in relative delta power, skewness, kurtosis, amplitude, and discontinuity across four EEG/HIE grades.
  • A linear combination of qEEG measures predicted EEG/HIE grade with 89% accuracy.
  • Key qEEG measures identified that differentiate HIE severity.

Conclusions:

  • Quantitative EEG analysis reveals associations between background EEG activity (amplitude, frequency, continuity) and visual HIE grading.
  • These qEEG measures are linked to expert visual interpretation of neonatal EEG.
  • This study is a crucial step towards automated EEG/HIE grade classification.