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Related Concept Videos

Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...

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Related Experiment Video

Updated: Jun 4, 2026

Generation of Monocyte-Derived Dendritic Cells with Differing Sialylated Phenotypes
13:36

Generation of Monocyte-Derived Dendritic Cells with Differing Sialylated Phenotypes

Published on: October 20, 2023

Syk-coupled C-type lectins in immunity.

Ann M Kerrigan1, Gordon D Brown

  • 1Section of Immunology and Infection, Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.

Trends in Immunology
|February 22, 2011
PubMed
Summary

Spleen tyrosine kinase-coupled C-type lectin receptors, like Dectin-1, are crucial for innate and adaptive immunity against various infections. These receptors mediate intracellular signaling, playing key roles in fungal, viral, and other pathogen responses.

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T Cells Capture Bacteria by Transinfection from Dendritic Cells
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Generation of Monocyte-Derived Dendritic Cells with Differing Sialylated Phenotypes
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T Cells Capture Bacteria by Transinfection from Dendritic Cells
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T Cells Capture Bacteria by Transinfection from Dendritic Cells

Published on: January 13, 2016

Area of Science:

  • Immunology
  • Molecular Biology
  • Infectious Diseases

Background:

  • Dectin-1, a spleen tyrosine kinase-coupled C-type lectin receptor, was the first non-Toll like receptor identified to mediate its own intracellular signaling.
  • Initially recognized for its role in fungal pathogen recognition and innate immunity, Dectin-1 also triggers adaptive immune responses.

Purpose of the Study:

  • To explore the capacity of spleen tyrosine kinase-coupled C-type lectin receptors to initiate diverse immune responses.
  • To highlight the emerging roles of these receptors in various infection contexts.

Main Methods:

  • Review of existing literature on Dectin-1 and related receptors.
  • Analysis of signaling pathways mediated by C-type lectin receptors.
  • Examination of immune responses in different infection models.

Main Results:

  • Spleen tyrosine kinase-coupled C-type lectin receptors are implicated in immunity beyond fungal infections, including viral, mycobacterial, and helminth infections.
  • These receptors mediate both innate and adaptive immune responses.
  • Dectin-1's signaling capability is central to its multifaceted immune functions.

Conclusions:

  • Spleen tyrosine kinase-coupled C-type lectin receptors are versatile mediators of immunity against a broad spectrum of pathogens.
  • Understanding these receptors' signaling mechanisms offers insights into novel therapeutic strategies for infectious diseases.