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A Human Fallopian Tube Model for Investigation of C. trachomatis Infections
Published on: August 11, 2012
[Chlamydia trachomatis infection in the first year of life]
J Martins1, C Ribeiro Luís, T Correia De Aguiar
1Departamento de Pediatria, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal. joana.jm@gmail.com
Insights
Chlamydia trachomatis (C. trachomatis) causes significant conjunctivitis and respiratory infections in infants. This study highlights its role in early childhood illness, suggesting it is likely underdiagnosed.
Area of Science:
- Pediatric Infectious Diseases
- Ophthalmology
- Respiratory Medicine
Context:
- Chlamydia trachomatis (C. trachomatis) is a prevalent bacterial sexually transmitted infection in women.
- Pregnant women can be asymptomatic carriers (2-20%), posing a risk to newborns (40-70% infection rate).
- Screening pregnant women for C. trachomatis is a debated topic.
Purpose:
- To characterize Chlamydia trachomatis infections in children under 12 months of age.
- To analyze demographic, clinical, imaging, and outcome data for pediatric C. trachomatis cases.
Summary:
- A retrospective study identified 46 children under 12 months with C. trachomatis infection (incidence 0.7/1,000 deliveries).
- Respiratory infections (89.1%) and conjunctivitis (36.9%) were common, with onset in early infancy.
- Complications included hypoxemia, otitis, apnea, and atelectasis; 80.5% of children had a good outcome.
Impact:
- C. trachomatis is a significant etiological agent for conjunctivitis and respiratory infections in infants.
- The study suggests C. trachomatis infection is underdiagnosed in Portugal.
- Highlights the need for increased awareness and potential screening strategies for C. trachomatis in neonates and infants.
Background:
Chlamydia trachomatis (C. trachomatis) is the most frequent bacterial sexual infection in women. Pregnant women screening is controversial, with asymptomatic colonization occurring in 2-20%, and 40-70% newborns can be infected.
Objectives:
The aim of this work is to characterise C. trachomatis infections in children under 12 months.
Material And Methods:
Retrospective study was carried out from January 1997 to December 2009 (13 years), on Chlamydia infections, diagnosed by immunofluorescence of ocular scraping or serum immunoglobulin M (IgM). Demographic, clinical features, imaging findings, and outcomes were analysed.
Results:
A total of 46 children were identified, with an overall incidence of 0.7/1,000 deliveries. Mean age was 2 months (range from 7 days to 11 months). Seven mothers had co-infections: Human Immunodeficiency Virus (HIV) (1), HBs antigen (HBsAg) (1) and group B Streptococcus (5). Most (81.4%) children had a vaginal delivery, with membrane rupture over 12 hours in 13.0%. Respiratory infection occurred in 41 (89.1%) cases and conjunctivitis in 17 (36.9%). Conjunctivitis manifested in the first 30 days of life (range from 7 days to 52 days). Respiratory symptoms occurred at age 45 days (range from 8 days to 11 months). Ten (29.4%) children had complications: hypoxemia (9), acute medial otitis (2), apnoea (3) and atelectasis (1). Chest X-ray revealed interstitial infiltrate in 25 (65.8%), and was normal in 4 children. Most children (80.5%) had a good outcome.
Conclusions:
C. trachomatis should be considered as an aetiologic agent of conjunctivitis and respiratory infections in the first year of life. The prevalence of C. trachomatis infection in Portugal is unknown, and is probably an underdiagnosed disease.
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