Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

Classification of Leukocytes

Classification of Leukocytes

Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sperm activation for fertilization requires robust activity of the TAT-5 lipid flippase.

Developmental biology·2025

Same author

The Caenorhabditis elegans spe-21 gene that encodes a palmitoyltransferase is necessary for spermiogenesis.

Developmental biology·2025

Same author

Sperm activation for fertilization requires robust activity of the TAT-5 lipid flippase.

bioRxiv : the preprint server for biology·2025

Same author

Utilizing <i>C. elegans</i> Spermatogenesis and Fertilization Mutants as a Model for Human Disease.

Journal of developmental biology·2025

Same author

Identification and sequencing of temperature sensitive alleles of the Anaphase Promoting Complex component <i>mat-3</i> in <i>C. elegans</i>.

microPublication biology·2023

Same author

The EGF-motif-containing protein SPE-36 is a secreted sperm protein required for fertilization in C. elegans.

Current biology : CB·2023

Search research articles

Related Experiment Video

Updated: Jun 4, 2026

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Published on: April 20, 2021

Germline determination: don't mind the P granules.

Matthew R Marcello¹, Andrew Singson

¹Department of Molecular Genetics, Microbiology and Immunology, UMDNJ-Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.

Current Biology : CB

|February 22, 2011

Summary

A novel role for PPTR-1, a subunit of phosphatase 2A, in P granule segregation was discovered. This finding challenges the established view of P granules

Area of Science:

Developmental Biology
Cell Biology
Genetics

Background:

P granules are essential for germline development in Caenorhabditis elegans.
Their role in germline determination has been a long-standing belief in the field.

Purpose of the Study:

To investigate the function of PPTR-1, the regulatory subunit of phosphatase 2A, in P granule dynamics.
To re-evaluate the role of P granules in germline determination.

Main Methods:

Utilized genetic and imaging techniques in Caenorhabditis elegans.
Observed P granule segregation patterns in the presence and absence of functional PPTR-1.

Main Results:

Identified a novel role for PPTR-1 in the segregation of P granules.

More Related Videos

Computational Analysis of the Caenorhabditis elegans Germline to Study the Distribution of Nuclei, Proteins, and the Cytoskeleton

Computational Analysis of the Caenorhabditis elegans Germline to Study the Distribution of Nuclei, Proteins, and the Cytoskeleton

Published on: April 19, 2018

In Situ Detection of Ribonucleoprotein Complex Assembly in the C. elegans Germline using Proximity Ligation Assay

In Situ Detection of Ribonucleoprotein Complex Assembly in the C. elegans Germline using Proximity Ligation Assay

Published on: May 5, 2020

Related Experiment Videos

Last Updated: Jun 4, 2026

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Published on: April 20, 2021

Computational Analysis of the Caenorhabditis elegans Germline to Study the Distribution of Nuclei, Proteins, and the Cytoskeleton

Computational Analysis of the Caenorhabditis elegans Germline to Study the Distribution of Nuclei, Proteins, and the Cytoskeleton

Published on: April 19, 2018

In Situ Detection of Ribonucleoprotein Complex Assembly in the C. elegans Germline using Proximity Ligation Assay

In Situ Detection of Ribonucleoprotein Complex Assembly in the C. elegans Germline using Proximity Ligation Assay

Published on: May 5, 2020

Demonstrated that PPTR-1 influences P granule localization independently of established germline determination pathways.

Conclusions:

PPTR-1 plays a critical, previously unrecognized role in P granule segregation.
The findings challenge the exclusive role of P granules in determining the germline fate.
Suggests a more complex regulatory mechanism for germline development in C. elegans.