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Updated: Jun 4, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
Published on: September 20, 2018
Cellular reprogramming: chromatin puts on the brake
1Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA. sengupta@brandeis.edu
Abstract:
Directed reprogramming of differentiated cells allows the generation of specific cell types for therapeutics and can provide unexpected insights into development. A recent study demonstrates that efficient reprogramming of Caenorhabditis elegans germ cells into neurons can be achieved by knocking down a histone chaperone gene and ectopic expression of a terminal selector transcription factor.
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