Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

LC Circuits

LC Circuits

An LC circuit consists of an inductor and a capacitor, either in series or parallel. Consider a charged capacitor connected with an inductor in series. Before the switch is closed, all the energy of the circuit is stored in the electric field of the capacitor. When the switch is closed, the capacitor begins to discharge, producing a current in the circuit. The current, in turn, creates a magnetic field in the inductor. Because of the induced emf in the inductor, the current cannot change...

Circuit Terminology

Circuit Terminology

An electrical network is a system composed of interconnected elements, such as resistors, capacitors, inductors, and voltage or current sources. Unlike a circuit, an electrical network does not necessarily form a closed path. In other words, while all circuits can be considered networks due to their interconnected nature, not every network qualifies as a circuit.
A circuit, on the other hand, is also an interconnected system of electrical elements but must contain one or more closed paths.

Disassembly of Intermediate Filaments

Disassembly of Intermediate Filaments

Intermediate filaments (IFs) do not undergo spontaneous disassembly. Enzymes, kinases, and phosphatases add and remove phosphates from specific sites to regulate their disassembly. The IF concentration in the cytoplasm also regulates the disassembly. If the concentration crosses a threshold, it activates the protein kinases in the vicinity, allowing the phosphorylation of IFs.
Keratin proteins, found at the cell periphery near cell junctions, undergo a cycle of assembly and disassembly. In Type...

Clamper Circuit

Clamper Circuit

A clamper circuit, also known as a DC restorer, represents a specialized variant of the rectifier circuit, notable for its method of taking the output across the diode rather than the capacitor. This configuration lends to several distinctive applications, particularly in handling square wave inputs.
Within this circuit, the diode's orientation prompts the capacitor to charge up to the level of the most negative peak of the input signal. Upon reaching this state, the diode ceases to conduct,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Preclinical <i>CRX</i> augmentation therapies for <i>CRX</i>-associated autosomal dominant cone-rod dystrophies.

bioRxiv : the preprint server for biology·2026

Same author

A genome-wide in vivo CRISPR screen identifies neuroprotective strategies in the mouse and human retina.

Neuron·2026

Same author

A genome-wide in vivo CRISPR screen identifies neuroprotective strategies in the mouse and human retina.

bioRxiv : the preprint server for biology·2025

Same author

Molecular mechanism establishing the OFF pathway in vision.

Nature communications·2025

Same author

Author Correction: Subcellular pathways through VGluT3-expressing mouse amacrine cells provide locally tuned object-motion-selective signals in the retina.

Nature communications·2024

Same author

A pupillary contrast response in mice and humans: Neural mechanisms and visual functions.

Neuron·2024

Search research articles

Related Experiment Video

Updated: Jun 4, 2026

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications

Published on: November 20, 2019

Circuit assembly: the repulsive side of lamination.

Daniel Kerschensteiner¹

¹Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA. KerschensteinerD@vision.wustl.edu

Current Biology : CB

|February 22, 2011

Summary

Repulsive signals between visual pathways organize neuronal connections. This study reveals how these signals create laminar circuits in the inner retina, advancing our understanding of neural development.

More Related Videos

Structural Design and Manufacturing of a Cruiser Class Solar Vehicle

Structural Design and Manufacturing of a Cruiser Class Solar Vehicle

Published on: January 30, 2019

A 3D-printed Chamber for Organic Optoelectronic Device Degradation Testing

A 3D-printed Chamber for Organic Optoelectronic Device Degradation Testing

Published on: August 10, 2018

Related Experiment Videos

Last Updated: Jun 4, 2026

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications

Published on: November 20, 2019

Structural Design and Manufacturing of a Cruiser Class Solar Vehicle

Structural Design and Manufacturing of a Cruiser Class Solar Vehicle

Published on: January 30, 2019

A 3D-printed Chamber for Organic Optoelectronic Device Degradation Testing

A 3D-printed Chamber for Organic Optoelectronic Device Degradation Testing

Published on: August 10, 2018

Area of Science:

Neuroscience
Developmental Biology
Visual System Research

Background:

Understanding neuronal circuit architecture is crucial for neuroscience.
The precise wiring of the visual system, particularly in the retina, is not fully understood.
Mechanisms governing the formation of specific neuronal connections, like laminar circuits, are a key research area.

Purpose of the Study:

To investigate the role of repulsive signaling in organizing neuronal connections.
To elucidate the mechanisms by which parallel visual pathways establish laminar circuits in the inner retina.

Main Methods:

The study likely involved in vivo or in vitro experiments observing neuronal development.
Techniques may include genetic manipulation, imaging, or electrophysiology to track pathway interactions and circuit formation.

Main Results:

Repulsive signaling between parallel visual pathways was identified as a key organizing principle.
This repulsive signaling was shown to be essential for the formation of precise laminar circuits in the inner retina.

Conclusions:

Repulsive signaling is a critical mechanism for establishing neuronal circuit architecture in the visual system.
The findings provide new insights into the developmental processes underlying retinal circuit organization.