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Zhen Huang1, Xiao-Ming Zhong, Zhao-Yi Li

  • 1College of Pharmacy, Zhejiang Chinese Medicine University, Hangzhou 310053, Zhejiang, China. zhen626@yahoo.com.cn

Neuroscience Letters
|February 22, 2011
PubMed
Summary
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Curcumin demonstrated antidepressant-like effects in a rat model of depression induced by corticosterone (CORT). This natural compound may work by increasing brain-derived neurotrophic factor (BDNF) in key brain regions.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Corticosterone (CORT) administration is a validated method for inducing depression-like behaviors in rodent models.
  • Depression is often associated with reduced levels of brain-derived neurotrophic factor (BDNF), particularly in the hippocampus and frontal cortex.
  • Curcumin, a compound found in turmeric, has shown potential therapeutic properties, including anti-inflammatory and antioxidant effects.

Purpose of the Study:

  • To investigate the antidepressant-like effects of curcumin in a rat model of depression induced by chronic corticosterone (CORT) administration.
  • To explore the potential mechanisms underlying curcumin's effects, focusing on brain-derived neurotrophic factor (BDNF) levels in the hippocampus and frontal cortex.

Main Methods:

  • Rats were administered corticosterone (CORT) for three weeks to induce depression-like behaviors.

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  • Depression-like behaviors were assessed using the sucrose consumption test and the forced swim test.
  • Brain-derived neurotrophic factor (BDNF) protein levels in the hippocampus and frontal cortex were measured.
  • Rats were treated with curcumin during the CORT administration period.

    • Main Results:

    • CORT administration significantly induced depression-like behaviors, evidenced by reduced sucrose preference and increased immobility time.
    • Repeated CORT injections led to a significant decrease in BDNF protein levels in the hippocampus and frontal cortex.
    • Curcumin treatment significantly attenuated the CORT-induced depression-like behaviors.
    • Curcumin treatment also prevented the decrease in BDNF levels in the hippocampus and frontal cortex.

    Conclusions:

    • Curcumin exhibits significant antidepressant-like effects in a rat model of CORT-induced depression.
    • The antidepressant-like effects of curcumin may be mediated by the upregulation of brain-derived neurotrophic factor (BDNF) in the hippocampus and frontal cortex.
    • These findings suggest that curcumin holds potential as a therapeutic agent for depression, possibly through mechanisms involving BDNF modulation.