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Related Experiment Video

Updated: Jun 4, 2026

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

Depression, anxiety, and arterial stiffness.

Adrie Seldenrijk¹, Hein P J van Hout, Harm W J van Marwijk

¹EMGO Institute for Health and Care Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. a.seldenrijk@vumc.nl

Biological Psychiatry

|February 22, 2011

Summary

Individuals with current depression or anxiety disorders exhibit increased arterial stiffness, specifically a higher central augmentation index. This finding suggests a link between mental health conditions and cardiovascular disease progression.

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Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

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Published on: October 19, 2016

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

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Published on: December 2, 2014

Area of Science:

Cardiology
Psychiatry
Vascular Biology

Background:

Arterial stiffness is a potential mechanism linking depression/anxiety with cardiovascular disease.
Previous studies on psychopathology and arterial stiffness used small samples.
This study investigates arterial stiffness in individuals with diagnosed depressive or anxiety disorders.

Purpose of the Study:

To determine if individuals with depressive or anxiety disorders have increased arterial stiffness.
To explore associations between specific psychiatric characteristics and arterial stiffness.

Main Methods:

449 cases with lifetime depressive/anxiety disorders and 169 controls (ages 20-66).
Assessed psychiatric characteristics: comorbidity, subtype, severity, duration, age of onset, medication.
Measured arterial stiffness using radial tonometry (AIx75) and carotid ultrasound (distensibility coefficient).

Main Results:

Current depression/anxiety associated with increased AIx75 (15.7% vs. 13.3% in controls, p=.01).
Higher AIx75 linked to comorbidity, greater depression/anxiety severity, and longer symptom duration.
No significant associations found for distensibility coefficient.

Conclusions:

Current depressive or anxiety disorders are associated with elevated central augmentation index, indicating arterial stiffness.
Depression and anxiety may accelerate atherosclerosis and cardiovascular conditions.