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Effects of physical exercise on lung injury and oxidant stress in children with asthma

Ozlem Gunay1, Ece Onur, Ozge Yilmaz

  • 1Celal Bayar University Medical Faculty, Dept of Biochemistry, Manisa, Turkey. ece.onur@bayar.edu.tr

Allergologia Et Immunopathologia
|February 22, 2011
PubMed

Insights

Exercise training significantly reduced endothelin-1 (ET-1) levels in children with asthma, suggesting a key role in managing lung inflammation and oxidative stress.

Area of Science:

  • Pediatric Pulmonology
  • Exercise Physiology
  • Biochemistry

Background:

  • Asthma in children is associated with oxidative stress and lung inflammation.
  • Exercise training's impact on these markers requires further investigation.

Purpose of the Study:

  • To examine the effects of exercise training on oxidative stress and lung inflammation markers in pediatric asthma.
  • To compare outcomes between children receiving pharmacotherapy alone versus those with added exercise.

Main Methods:

  • Thirty children (8-13 years) with asthma and 13 healthy controls were studied.
  • Asthma patients were divided into pharmacotherapy-only and pharmacotherapy plus exercise groups.
  • Biomarkers including Leukotriene E4, malondialdehyde (MDA), matrix metallopeptidase-9 (MMP-9), and endothelin-1 (ET-1) were measured.

Main Results:

  • Leukotriene E4, MDA, and MMP-9 levels decreased significantly in both asthma treatment groups.
  • Endothelin-1 (ET-1) levels showed a significant decrease exclusively in the exercise group.
  • ET-1 levels were significantly lower in the exercise group compared to the pharmacotherapy-only group.

Conclusions:

  • Exercise training demonstrates positive effects in pediatric asthma management.
  • The reduction in endothelin-1 (ET-1) may be a primary mechanism mediating these benefits.
  • Exercise may offer an adjunctive therapy for improving asthma control.
Abstract

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