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10:33
An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
Published on: May 24, 2024
The use of selective volatization in the separation of 68Ge from irradiated Ga targets
N P van der Meulen1, S G Dolley, G F Steyn
1iThemba LABS, Somerset West 7129, South Africa. nick@tlabs.ac.za
Abstract:
Cyclotron-produced (68)Ge can be separated from its Ga target material by dissolving the target in aqua regia and collecting the volatile (68)Ge in a solution containing 1.0M NaOH and 2% Na₂SO₃. The solution is then acidified with HF before being loaded onto a column containing AG MP-1 anion exchange resin. The column is rinsed with dilute HF to remove any remaining impurities, before eluting the desired product with 0.1M HCl. A radiochemically pure product is obtained.
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