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Related Experiment Videos

[Pseudotumor cerebri induced by danazol].

M Loukili1, M Cordonnier, E Capelluto

  • 1Service d'Ophtalmologie, Hôpital Universitaire Erasme, Cliniques Universitaires de Bruxelles, Belgique.

Bulletin De La Societe Belge D'Ophtalmologie
|January 1, 1990
PubMed
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Danazol, used to treat paroxysmal nocturnal hemoglobinuria, can cause benign intracranial hypertension. This condition, also known as pseudo-tumor cerebri, resolved after discontinuing Danazol treatment.

Area of Science:

  • Internal Medicine
  • Pharmacology
  • Neurology

Background:

  • Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, clonal hematopoietic stem cell disorder.
  • Danazol is a synthetic steroid derivative used in the treatment of PNH and other conditions.
  • Benign intracranial hypertension (BIH), or pseudo-tumor cerebri, is a neurological disorder characterized by increased intracranial pressure without a detectable mass lesion.

Observation:

  • A 39-year-old woman with PNH developed symptoms of benign intracranial hypertension during Danazol therapy.
  • The patient presented with bilateral papilledema, a key sign of increased intracranial pressure.
  • Sclerosing cholangitis was also noted in this patient, a condition characterized by inflammation and scarring of the bile ducts.

Findings:

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  • The papilledema resolved within four weeks of discontinuing Danazol treatment, indicating a direct link between the drug and the neurological condition.
  • This case report aligns with twelve previously documented instances of Danazol-induced pseudo-tumor cerebri in the medical literature.
  • The findings suggest a potential causal relationship between Danazol and the development of benign intracranial hypertension.

Implications:

  • Danazol should be recognized as a potential iatrogenic cause of pseudo-tumor cerebri.
  • Clinicians should consider Danazol-induced BIH in patients presenting with symptoms of increased intracranial pressure, particularly those undergoing treatment for PNH.
  • Further research may be warranted to elucidate the precise mechanism by which Danazol induces BIH and to establish clear diagnostic and management guidelines.