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Novel 3D/VR Interactive Environment for MD Simulations, Visualization and Analysis

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Published on: December 18, 2014

Three dimensional projection environment for molecular design and surgical simulation.

Eric Wickstrom¹, Chang-Po Chen, Devakumar Devadhas

¹Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Studies in Health Technology and Informatics

|February 22, 2011

Summary

Researchers are creating new PET imaging agents and software to simulate pancreatic cancer surgery in 3D. This technology fuses positron emission tomography (PET) and computerized tomography (CT) scans for enhanced surgical planning.

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Area of Science:

Oncology
Medical Imaging
Surgical Simulation

Background:

Pancreatic cancer diagnosis and surgical planning require advanced imaging techniques.
Current methods lack the ability to provide tactile feedback for surgical simulation.
Targeting cancer-specific biomarkers can improve diagnostic accuracy.

Purpose of the Study:

To develop novel positron emission tomography (PET) agents for imaging cancer gene mRNA expression.
To create software for fusing mRNA PET and computerized tomography (CT) images.
To enable volumetric, haptic (3D touch-and-feel) surgical simulation of pancreatic cancer.

Main Methods:

Identification of a novel ligand targeting the epidermal growth factor receptor (EGFR) for specific PET agent uptake in cancer cells.
Development of software to fuse mRNA PET and CT imaging data.
Reconstruction of patient-specific 3D haptic surgical simulations from CT data.
Adjustment of tissue properties (Young's modulus, Poisson ratio) based on surgeon feedback.

Main Results:

A novel EGFR-specific ligand has been identified for targeted PET imaging.
A volumetric haptic surgical simulation of human pancreatic cancer has been successfully created.
The simulation is reconstructed from patient CT data, offering patient-specific planning.

Conclusions:

This integrated approach combines advanced PET imaging with 3D haptic simulation for improved pancreatic cancer surgical planning.
The developed technology has the potential to enhance pre-surgical understanding and execution.
Personalized surgical simulation can lead to better patient outcomes.