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[Disorders of ventricular rhythm in acute myocardial infarct]
1University School of Medicine Hospital, Zemun.
Insights
Preventive administration of xylocaine and calcium antagonists can reduce ventricular arrhythmias following acute myocardial infarction. These arrhythmias remain a significant cause of mortality in heart attack patients.
Area of Science:
- Cardiology
- Electrophysiology
Context:
- Acute myocardial infarction (AMI) frequently leads to life-threatening ventricular arrhythmias.
- Ischemia-induced cellular electrical changes can trigger reentry and automatic mechanisms, causing these arrhythmias.
Purpose:
- To analyze the occurrence and outcomes of ventricular arrhythmias in patients with acute myocardial infarction.
- To evaluate the preventive efficacy of xylocaine and calcium antagonists.
Summary:
- A study of 210 acute myocardial infarction patients investigated ventricular arrhythmias.
- Preventive xylocaine showed favorable effects; novocamide was also used in some cases.
- Calcium antagonists administered early also contributed to arrhythmia prevention.
Impact:
- While preventive measures reduced arrhythmia frequency, they were fatal in 52.3% of cases.
- Highlights the critical need for effective arrhythmia management post-myocardial infarction.
Abstract:
Ventricular arrhythmias are one of the major immediate complication of acute myocardial infarction because they can provoke haemodynamical abnormalities, enlargement of infarction and sudden death. Different electrical reactions in the cell induced by ishaemia can provoke later contraction "reentry" mechanism and appearance of automatic contraction, and thus ventricular arrhythmias. Ventricular arrhythmias were analyzed in 210 patients with acute myocardial infarction. A very favourable effect was obtained with preventively given xylocain and in some patients, novocamid. Calcium antagonists were also given to the patients from the beginning and the also contributed to this good preventive effect. Ventricular arrhythmias were rare, but they were the cause of death in 52.3% of our patients.