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Related Experiment Video

Updated: Jun 4, 2026

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions
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Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions

Published on: March 20, 2014

Palladium-mediated intracellular chemistry.

Rahimi M Yusop1, Asier Unciti-Broceta, Emma M V Johansson

  • 1School of Chemistry, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, UK.

Nature Chemistry
|February 22, 2011
PubMed
Summary
This summary is machine-generated.

Researchers developed palladium nanoparticles within microspheres that can enter cells. These nanoparticles catalyze reactions inside cells, enabling new tools for cellular manipulation and synthesis.

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Area of Science:

  • Biochemistry
  • Nanotechnology
  • Cell Biology

Background:

  • Intracellular biochemical reactions are often regulated by transition metals within metalloproteins.
  • Selective chemical transformations within cells are crucial for manipulating biological processes.

Purpose of the Study:

  • To develop novel intracellular catalysts for artificial chemistry.
  • To demonstrate the feasibility of using palladium nanoparticles for in cellulo reactions.

Main Methods:

  • Encapsulation of palladium nanoparticles within polystyrene microspheres.
  • Introduction of these microspheres into cells.
  • Catalysis of palladium(0)-mediated reactions, including allylcarbamate cleavage and Suzuki-Miyaura cross-coupling.

Main Results:

  • Palladium nanoparticles successfully entered cells.
  • The nanoparticles effectively mediated various Pd(0)-catalyzed reactions within the cellular environment.
  • Demonstrated the potential for heterogeneous unnatural catalysts in cellular synthesis.

Conclusions:

  • Customized heterogeneous unnatural catalysts can be developed for intracellular applications.
  • In cellulo synthesis using these catalysts opens possibilities for cellular labeling and functional modulation.