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Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix
08:49

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Published on: July 10, 2016

NME genes in epithelial morphogenesis.

Tien Hsu1

  • 1Department of Medicine, Boston University School of Medicine, 650 Albany St., Room 440, Boston, MA 02118, USA. tienh@bu.edu

Naunyn-Schmiedeberg'S Archives of Pharmacology
|February 22, 2011
PubMed
Summary
This summary is machine-generated.

The NME gene family

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • NME gene family proteins are multifunctional, involved in nucleic acid metabolism, energy, signaling, and cancer.
  • NME isoforms 1 and 2 show anti-metastasis potential, but mechanisms are unclear due to diverse protein functions.
  • Conflicting clinical data on NME expression and tumor progression necessitate in vivo studies.

Purpose of the Study:

  • To review recent findings on NME gene functions in epithelial cell motility and morphogenesis.
  • To explore the role of NME in regulating growth factor receptors and cell adhesion molecules.
  • To discuss the implications of NME's biphasic function in cancer progression and anti-metastasis.

Main Methods:

  • Utilized the Drosophila genetic system to investigate NME's role in epithelial cell motility.
  • Examined NME's effects on growth factor receptor internalization in motile cells.
  • Analyzed NME's impact on adherens junction components (E-cadherin, β-catenin) in epithelial tissues.

Main Results:

  • NME regulates epithelial cell motility and morphogenesis in Drosophila and mammalian cells.
  • NME promotes internalization of growth factor receptors and adherens junction proteins.
  • NME exhibits a biphasic function, with both down-regulation and over-expression disrupting epithelial integrity.

Conclusions:

  • NME's role in regulating epithelial cell dynamics provides mechanistic insight into its anti-metastatic and potential oncogenic functions.
  • The biphasic nature of NME expression explains contradictory clinical observations.
  • Further research in pliable in vivo systems is crucial for understanding NME's complex roles.