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Direct-acting antiviral therapy for hepatitis C: attitudes regarding future use
Paul J Gaglio1, Noah Moss, Camille McGaw
1Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA. pgaglio@montefiore.org
Digestive Diseases and Sciences
|February 22, 2011
Summary
Practitioners are aware of direct-acting antiviral (DAA) therapies for hepatitis C virus (HCV) but may increase referrals to specialists. Education is crucial to prevent inappropriate DAA use.
Area of Science:
- Hepatology
- Infectious Diseases
- Clinical Pharmacy
Background:
- Current hepatitis C virus (HCV) therapies have suboptimal response rates.
- Direct-acting antiviral (DAA) therapies promise improved outcomes but increase treatment complexity.
- Practitioner perceptions of DAA complexity may influence future treatment attitudes.
Purpose of the Study:
- To assess healthcare providers' awareness and attitudes towards direct-acting antiviral (DAA) therapies for hepatitis C virus (HCV).
- To evaluate potential shifts in treatment and referral patterns with the advent of DAAs.
- To identify potential challenges and educational needs regarding DAA utilization.
Main Methods:
- An internet-based survey was distributed to 10,082 members of the AASLD and AGA.
- Survey assessed current HCV treatment practices, DAA knowledge, and attitudes towards current and future therapies.
- Responders' participation in DAA clinical trials and referral intentions were also evaluated.
Main Results:
- Of 1,757 respondents, 75% treat HCV, and 77% are aware of DAAs.
- While most are willing to treat with DAAs, a significant increase in referrals to HCV experts is anticipated (6% to 10%).
- Over half of providers with minimal DAA knowledge intend to use them, raising concerns.
Conclusions:
- The majority of surveyed providers are prepared to adopt DAAs, but increased specialist referrals are expected.
- A substantial proportion of providers with limited DAA knowledge plan to use these agents, highlighting a need for education.
- Comprehensive education is critical to ensure appropriate and effective utilization of DAAs and prevent misuse.
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