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Sp1 collagen I A1 polymorphism in women with stress urinary incontinence
Dimos Sioutis1, Emmanuel Economou, Irene Lambrinoudaki
1Second Department of Obstetrics and Gynecology, University of Athens, Aretaieio Hospital, Athens, Greece.
Introduction And Hypothesis:
Stress urinary incontinence (SUI) is in part attributed to qualitative and quantitative changes in connective tissue of the urogenital tract. We examined the association of collagen type I a1 (COLIA 1) Sp1 polymorphism with the risk of SUI.
Methods:
Forty-five postmenopausal women suffering from urodynamically verified SUI (study group) were compared to 45 healthy volunteers (control). DNA was extracted from peripheral blood. The genotyping concerning the type 1 a1 collagen gene Sp1 polymorphism was performed with polymerase chain reaction.
Results:
The polymorphic T allele was overrepresented in the SUI patients (63.2% versus 36.8%, p = 0.016). Odds ratio for SUI in women harboring the T allele was 2.19 (95% CI 1.149-4.176) compared to women with the wild-type genotype.
Conclusions:
The COLIA1 Sp1 polymorphism is associated with increased prevalence of stress urinary incontinence in postmenopausal women.
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