Cytotoxicity of oxide anodized titanium alloy evaluated by cell and organic culture study

The cytotoxic effects of an oxide-anodized titanium alloy were investigated by cell and organic culture studies. Toxicity was estimated based on cell survival and growth rates compared with those of control materials (glass) after cultivation of cells (L 929) and chicken embryonic femurs expose to alloy plates. The oxide-anodized titanium alloy showed no cytotoxicity with respect to survival or growth rates in either cells or chicken embryonic femurs. Furthermore, the oxide-anodized titanium alloy was more acid and alkali resistant than intact titanium alloys. The results suggest that oxide-anodized titanium has greater stability and its metallic ions may be leachedless under various conditions following dental implantations. Therefore, this alloy should be suitable for use as a dental implant material.