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Brain perfusion abnormalities in patients with compromised venous outflow
Ribal S Darwish1, Nana S Amiridze
1Critical Care Medicine Division, Department of Anesthesiology, University of Maryland Medical Center, 22 S. Greene Street, Baltimore, MD 21201-1595, USA. Rdarwish@anes.umm.edu
Journal of Neurology
|February 22, 2011
Summary
Diagnosing elevated intracranial venous pressure may be possible using CT brain perfusion studies. Abnormal venous time-density curves correlate with increased pressure and normalize after treatment.
Area of Science:
- Neurology
- Radiology
- Vascular Medicine
Background:
- Intracranial venous pressure is not routinely measured.
- Indirect indicators include cerebral sinus size changes and venous infarctions.
Observation:
- This study evaluated venous time-density curves from CT brain perfusion scans in four patients.
- Abnormal curves were observed in patients with elevated intracranial venous pressure.
Findings:
- Venous time-density curves correlated with clinical findings of increased venous pressure.
- Curves normalized after treatment of the underlying cause.
- Abnormal venous outflow impacts brain perfusion, detectable via CT perfusion studies.
Implications:
- CT brain perfusion studies may offer a diagnostic tool for cerebral venous hypertension.
- Characteristic venous time-density curves can indicate venous outflow abnormalities.
- Normalization of these curves post-treatment suggests therapeutic efficacy.
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