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Measurement of exhaled hydrocarbons

P Paredi¹, S A Kharitonov, P J Barnes

¹Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Science, Technology and Medicine, London, UK.

Methods in Molecular Medicine

|February 22, 2011

Abstract:

Oxidative stress is implicated in the pathogenesis and progression of asthma (1,2), chronic obstructive respiratory disease (COPD) (3), and cystic fibrosis (4). Reactive oxygen species (ROS) are unstable compounds with unpaired electrons, capable of initiating oxidation. Several of the inflammatory cells which participate in the inflammatory response, such as macrophages, neutrophils, and eosinophils release increased amounts of ROS (1,5) exceeding the already reduced tissue antioxidant defences of asthmatic and COPD patients (2).

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