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Antibodies for inflammatory disease : effector cells

R Smith1

  • 1Academic Renal Unit, Southmead Hospital, Bristol, UK.

Methods in Molecular Medicine
|February 22, 2011
PubMed

Their inherent specificity makes antibodies attractive immunotherapeutic agents. Definition of appropriate therapeutic strategies requires parallel identification of potential target molecules and the immunotherapeutic mechanisms to be recruited by antibodies targeting these molecules. Regardless of the target antigen, antibodies may modify immune responses by: 1. Killing target cells (cytotoxic or depleting antibodies); 2. Blocking molecular interactions; 3. Modulating target molecules from the surface of cells; or 4. Modifying cell function as a consequence of signal transduction by ligated molecules.

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