Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Benefits of BCG-induced metabolic switch from oxidative phosphorylation to aerobic glycolysis in autoimmune and nervous system diseases.

Journal of internal medicine·2020
Same author

Targeted killing of TNFR2-expressing tumor cells and T<sub>regs</sub> by TNFR2 antagonistic antibodies in advanced Sézary syndrome.

Leukemia·2018
Same author

Low levels of C-peptide have clinical significance for established Type 1 diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2015
Same author

The promise of Hox11+ stem cells of the spleen for treating autoimmune diseases.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2008
Same author

Splenectomy: a new treatment option for ALL tumors expressing Hox-11 and a means to test the stem cell hypothesis of cancer in humans.

Leukemia·2007
Same author

The therapeutic potential of tumor necrosis factor for autoimmune disease: a mechanistically based hypothesis.

Cellular and molecular life sciences : CMLS·2005

Related Experiment Video

Updated: Jun 4, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

Antibodies for transplantation.

D L Faustman1

  • 1Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts General Hospital, Charlestown, MA.

Methods in Molecular Medicine
|February 22, 2011
PubMed
Summary

Antibodies are crucial in transplantation, helping to reduce immune responses and mask donor antigens. This approach involves inactivating T cells and eliminating immunogenic cells to prevent graft rejection.

Area of Science:

  • Immunology
  • Transplantation Medicine

Background:

  • Antibody therapy is an established clinical strategy in organ transplantation.
  • Antibodies modulate the recipient's immune system and donor graft immunogenicity.

Purpose of the Study:

  • To elucidate the multifaceted roles of antibodies in transplantation.
  • To detail antibody applications in preventing immune-mediated graft damage.

Main Methods:

  • Review of traditional antibody administration protocols.
  • Analysis of antibody mechanisms in T cell inactivation.
  • Examination of antibody-mediated antigen masking and cell elimination.

Main Results:

  • Antibodies effectively dampen recipient immune responses.

More Related Videos

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Related Experiment Videos

Last Updated: Jun 4, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

  • Antibodies can be used to obscure donor graft immunogenicity.
  • Specific antibody applications include T cell inactivation and passenger cell removal.

    • Conclusions:

    • Antibodies play a vital dual role in transplantation success.
    • Strategic antibody use enhances graft survival by managing immune responses and antigen presentation.