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New norditerpenoid alkaloids from Scutellaria barbata with cytotoxic activities
Sheng-Jun Dai1, Wei-Bing Peng, Li Shen
1School of Pharmaceutical Science, Yantai University, Yantai 264005, P.R. China. daishengjun_9@hotmail.com
Natural Product Research
|February 22, 2011
Abstract:
Two new norditerpenoid alkaloids, named scutebarbatines M-N (1 and 2), were isolated from the whole plant of Scutellaria barbata D. Don. Their structures were established on the basis of detailed spectral analyses. In vitro, two new compounds showed significant cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma and HT29 colorectal carcinoma cells), and gave IC₅₀ values in the range of 3.5-6.3 µM.