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Published on: June 15, 2018
Report of a novel mutation in the PMP22 gene causing an axonal neuropathy
Burkhard Gess1, Astrid Jeibmann, Anja Schirmacher
1Department of Neurology, University of Münster, Albert-Schweitzer Strasse 33, Münster 48149, Germany.
Introduction:
Point mutations in the peripheral myelin protein 22 (PMP22) gene rarely cause the hereditary neuropathies Charcot-Marie-Tooth disease type 1A (CMT1A) and hereditary neuropathy with liability to pressure palsies (HNPP), both of which show a demyelinating phenotype.
Methods:
In this study we characterized a family with an axonal neuropathy.
Results:
Three family members carried a heterozygous point mutation of the PMP22 gene, resulting in amino acid substitution R159C. Screening of 185 healthy controls did not reveal the R159C allele in any case.
Discussion:
The novel R159C mutation represents a very rare case of a dominant PMP22 mutation causing an axonal neuropathy.
