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Related Experiment Video

Updated: Jun 4, 2026

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
02:09

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Published on: April 12, 2024

Imaging lung microstructure in mice with hyperpolarized 3He diffusion MRI.

Wei Wang1, Nguyet M Nguyen, Dmitriy A Yablonskiy

  • 1Department of Physics, Washington University, St. Louis, Missouri 63110, USA.

Magnetic Resonance in Medicine
|February 22, 2011
PubMed
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This study successfully adapted 3He MRI lung morphometry for in vivo mouse studies. The noninvasive technique accurately measures lung microstructure, aiding early pulmonary disease detection in mouse models.

Area of Science:

  • Pulmonary Medicine
  • Medical Imaging
  • Quantitative Biology

Background:

  • Accurate measurement of lung microstructure is crucial for early pulmonary disease detection.
  • Previous MRI-based 3He lung morphometry was validated in humans and applied ex vivo to mouse lungs.
  • The technique provides quantitative data on acinar airway microstructure and geometry.

Purpose of the Study:

  • To implement and validate 3He lung morphometry for in vivo studies in mice.
  • To assess the agreement between in vivo MRI morphometry and ex vivo microscopic morphometry.
  • To establish 3He MRI morphometry as a noninvasive in vivo biomarker for lung disease research in mice.

Main Methods:

  • Adaptation of MRI-based 3He lung morphometry for in vivo application in mice.

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Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation
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Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation

Published on: November 21, 2023

Related Experiment Videos

Last Updated: Jun 4, 2026

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
02:09

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Published on: April 12, 2024

Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation
09:08

Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation

Published on: November 21, 2023

  • Quantitative analysis of lung microstructure and acinar airway geometry using 3He MRI.
  • Comparison of in vivo morphometry results with ex vivo microscopic morphometry data post-sacrifice.

    • Main Results:

    • Successful implementation of 3He lung morphometry for in vivo mouse studies.
    • Excellent agreement observed between in vivo 3He MRI morphometry and ex vivo microscopic morphometry.
    • Demonstration of the technique's capability for precise, noninvasive in vivo measurements.

    Conclusions:

    • 3He lung morphometry is a viable and accurate noninvasive technique for in vivo lung microstructure assessment in mice.
    • This method offers a new avenue for studying lung disease progression and therapeutic effects in mouse models.
    • The technique serves as a sensitive biomarker for detecting subtle changes in lung microstructure in preclinical research.