[Multifactorial analysis of the results of integrated radiation study in breast cancer]

Breast cancer can be successfully diagnosed at its early stage on the basis on the detailed analysis of its clinical and radiation signs, by keeping in mind the significance of multiple factors that influence the development of the tumor. Among these factors, the endogenous causes associated with female menstrual status in particular, and the states caused by the cytohistological features of the occurred cancer are of particular importance. To assess the significance of these factors, the authors examined a set of clinical, mammographic, and ultrasound data from 120 women of different ages with the breast cancer established and verified by cytohistological examination. The findings were compared in relation to the menstrual status (pre- and postmenopausal age) at the first stage and to the sizes of a cancer nodule detected by mammography at the second stage. A number of clinical and X-ray signs of cancer were noted to be associated with premenopausal age (the uneven pattern of a skin-matted nodule, enlarged lymph nodes, limited skin thickening, oval mottled tumor shadow with prominences and frequent calcifications) and others are substantially more frequently seen in menopause (the outlines of a tumor nodule with prominences, as well as altered adjacent tissues as prominences and strands). Assessing the pattern of changes in relation to the sizes of a tumor revealed ascertained that the development of the signs of invasive tumor growth was associated with the altered low-grade cancer/ moderate-grade tumor extent ratio.