Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Control Governance: Regulatory Bodies and Their Impact

Drug Control Governance: Regulatory Bodies and Their Impact

Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with a...

Drug Abuse and Addiction: Pharmacological Phenomena

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...

Drug Regulation

Drug Regulation

Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...

An Overview of Psychoactive Drugs

An Overview of Psychoactive Drugs

Psychoactive drugs impact brain function, influencing perception, mood, consciousness, cognition, and behavior. These substances are grouped based on their effects and the mechanisms by which they act.
Stimulants such as cocaine, amphetamines, and nicotine enhance brain activity, leading to increased alertness, attention, and energy. These drugs typically raise heart rate, blood pressure, and body temperature. While they can induce feelings of euphoria, their misuse can result in severe health...

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.

Drug Toxicity: Dose-Dependent Reactions

Drug Toxicity: Dose-Dependent Reactions

Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Profile of a drunk driver and risk factors for drunk driving. Findings in roadside testing in the province of Uusimaa in Finland 1990-2008.

Forensic science international·2013

Same author

Validation of self reported smoking by serum cotinine measurement in a community-based study.

Journal of epidemiology and community health·2002

Same author

A comparison between on-site immunoassay drug-testing devices and laboratory results.

Forensic science international·2001

Same author

Comparison of eight commercial on-site screening devices for drugs-of-abuse testing.

Scandinavian journal of clinical and laboratory investigation·2001

Same author

GCD quantitation of opiates as propionyl derivatives in blood.

Journal of analytical toxicology·2000

Same author

Drugged driving in the Nordic countries--a comparative study between five countries.

Forensic science international·2000

Search research articles

Related Experiment Video

Updated: Jun 4, 2026

Driving Under the Influence: How Music Listening Affects Driving Behaviors

Driving Under the Influence: How Music Listening Affects Driving Behaviors

Published on: March 27, 2019

Drugs and driving: the Finnish perspective.

P Lillsunde¹, T Gunnar

¹National Public Health Institute of Finland, Helsinhi.

Bulletin on Narcotics

|February 23, 2011

Summary

Drug impairment affects driving safety, with biological testing and legislation addressing driving under the influence. Saliva testing is emerging, but blood tests remain standard for drug-impaired driving cases.

Area of Science:

Forensic Toxicology
Traffic Safety Research
Pharmacology

Background:

Drug use significantly impairs driving ability, posing risks to public safety.
Legislation worldwide addresses driving under the influence (DUI) of alcohol and drugs.
Zero-tolerance laws and emerging roadside testing methods are evolving.

Purpose of the Study:

To review current practices and challenges in detecting drug-impaired driving.
To highlight the prevalence of various drugs affecting driving performance.
To discuss the role of biological fluid testing in legal proceedings.

Main Methods:

Review of existing legislation and testing protocols for drug-impaired driving.
Analysis of epidemiological data on drug use prevalence in driving populations.

More Related Videos

Tactile Vibrating Toolkit and Driving Simulation Platform for Driving-Related Research

Tactile Vibrating Toolkit and Driving Simulation Platform for Driving-Related Research

Published on: December 18, 2020

Driving Simulation in the Clinic: Testing Visual Exploratory Behavior in Daily Life Activities in Patients with Visual Field Defects

Driving Simulation in the Clinic: Testing Visual Exploratory Behavior in Daily Life Activities in Patients with Visual Field Defects

Published on: September 18, 2012

Related Experiment Videos

Last Updated: Jun 4, 2026

Driving Under the Influence: How Music Listening Affects Driving Behaviors

Driving Under the Influence: How Music Listening Affects Driving Behaviors

Published on: March 27, 2019

Tactile Vibrating Toolkit and Driving Simulation Platform for Driving-Related Research

Tactile Vibrating Toolkit and Driving Simulation Platform for Driving-Related Research

Published on: December 18, 2020

Driving Simulation in the Clinic: Testing Visual Exploratory Behavior in Daily Life Activities in Patients with Visual Field Defects

Driving Simulation in the Clinic: Testing Visual Exploratory Behavior in Daily Life Activities in Patients with Visual Field Defects

Published on: September 18, 2012

Examination of drug types most commonly associated with impaired driving.

Main Results:

Prevalence of illicit drug use in European drivers estimated at 1-5%, with licit drugs like benzodiazepines affecting 5-10%.
Drivers suspected of DUI show high rates of licit and illicit drug use.
Amphetamines, cocaine, cannabis, opiates, and benzodiazepines are key drugs of concern.

Conclusions:

Biological testing of fluids is crucial for documenting drug impairment in drivers.
Saliva testing shows promise for roadside screening, complementing traditional blood tests.
Continued research is needed to address the complexities of drug-impaired driving and its detection.