Initial structural studies of charged receptors that bind to inorganic phosphate anion and to an anionic phospholipid
Manjula B Koralegedara1, Hong W Aw, Dennis H Burns
1Department of Chemistry, Wichita State University, Wichita, Kansas 67260, USA.
The Journal of Organic Chemistry
|February 23, 2011
Abstract:
ITC titration studies of a family of bis-ammonium receptors based upon a scaffold of two bis-linked phenol rings show that several of the receptors bind to both dihydrogenphosphate and phosphatidylglycerol anions in a similar binding motif. Thermodynamic properties determined from ITC show that anion binding is entropy driven. Job plots determined from (1)H NMR clearly demonstrate that anion-receptor binding stoichiometry is dependent on the receptor's length of its bis-amine linkage.
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