Related Experiment Video
Updated: Jun 4, 2026
Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
Myeloid antigen positivity in Turkish children with acute lymphoblastic leukemia lacks influence on prognosis
Atila Tanyeli1, Fatih Erbey, Ibrahim Bayram
1Department of Pediatric Oncology, Cukurova University Faculty of Medicine, Adana, Turkey.
Introduction:
Several studies have suggested that the presence of myeloid antigens is a poor prognostic factor in patients with acute lymphoid leukemia (ALL).
Objective:
We aimed to assess this possibility in Turkish patients.
Materials And Methods:
Seventy-three children with a diagnosis of ALL-L1 and 38 with ALL-L2 were included. Flow cytometry and fluorescein-isothiocynate conjugated antibodies were used to determined surface antigens on blasts.
Results:
Myeloid antigens were positive in 48.4% with ALL-L1 and 60.5% with ALL-L2, the difference not being significant. Overall survival rates of myeloid antigen positive patients at 36, 60, and 72 months were 76%, 58%, and 48%, respectively, comparable to the corresponding 70%, 56%, and 46% in myeloid antigen negative patients (p >0.05).
Conclusion:
We did not find any association between myeloid antigen positivity and clinical and laboratory features of ALL.
More Related Videos
09:57Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
Published on: March 5, 2018
10:49Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013