Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 4, 2026

Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats
10:28

Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats

Published on: December 5, 2017

Proteome analysis in cardiovascular pathophysiology using Dahl rat model.

Thomas Grussenmeyer1, Silvia Meili-Butz, Volker Roth

  • 1Department of Biomedicine, University Hospital Basel, Hebelstrasse 20, Basel, Switzerland. t.grussenmeyer@unibas.ch

Journal of Proteomics
|February 23, 2011
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Heart failure with preserved ejection fraction: The role of intravascular volumes and body composition in exercise-induced progenitor cell mobilization.

International journal of cardiology. Heart & vasculature·2026
Same author

Centenary of Jaroslav Šterzl : This article celebrates the fact that the fields of immunology in the East and West are now on par, which is largely thanks to the genius and perseverance of Jaroslav Šterzl.

Folia microbiologica·2026
Same author

Neuregulin-1β Mitigates Doxorubicin-Induced Cardiotoxicity via <i>Serping1</i> in Cardiac Fibroblasts.

International journal of molecular sciences·2026
Same author

Staged hybrid repair of a symptomatic post-traumatic aortic aneurysmatic lesion in a patient with late diagnosed connective tissue disorder.

Journal of cardiothoracic surgery·2026
Same author

Engineering of bacterial cellulose-based vascular grafts for small-diameter applications.

Biomaterials advances·2026
Same author

Decoding Fibroblast Diversity Associated with the Postnatal Loss of Cardiac Regenerative Capacity.

International journal of molecular sciences·2026

Dahl salt-sensitive and salt-resistant rats show significant protein expression differences in heart tissue. These findings in the Dahl rat model are crucial for understanding heart failure mechanisms.

Area of Science:

  • Cardiovascular Research
  • Proteomics
  • Biomarker Discovery

Background:

  • Dahl salt-sensitive (DS) and salt-resistant (DR) rats are established models for cardiovascular research.
  • DS rats develop hypertension, left ventricular hypertrophy, and heart failure on a high-salt diet.
  • Identifying biomarkers for cardiac pathophysiology stages is essential.

Purpose of the Study:

  • To establish proteomic differences between DS and DR rat lines.
  • To investigate the suitability of the Dahl rat model for identifying cardiac biomarkers.
  • To lay the groundwork for monitoring heart failure development in the second stage of research.

Main Methods:

  • Comparative proteomic analysis of left ventricular tissues from DS and DR rats.
  • Utilizing statistical methods including Principal Component Analysis (PCA) and Linear Discriminant Analysis (LDA).

More Related Videos

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
08:09

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

Related Experiment Videos

Last Updated: Jun 4, 2026

Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats
10:28

Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats

Published on: December 5, 2017

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
08:09

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

  • Focusing on protein expression profiles under a low-salt diet condition.

    • Main Results:

    • Substantial quantitative and qualitative protein expression differences were detected between DS and DR rat hearts.
    • Sets of differentially expressed proteins were identified using statistical analyses.
    • These identified proteins are candidates for further investigation into heart failure mechanisms.

    Conclusions:

    • Significant proteomic variations exist between Dahl rat strains even before high-salt diet induction.
    • The identified differentially expressed proteins serve as potential biomarkers for cardiac conditions.
    • This study successfully established baseline proteomic profiles for the Dahl rat model in cardiovascular research.