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Updated: Jun 4, 2026

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience
Published on: August 26, 2014
Neuroscience of behavioral and pharmacological treatments for addictions
Marc N Potenza1, Mehmet Sofuoglu, Kathleen M Carroll
1Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA. marc.potenza@yale.edu
Abstract:
Although substantial advances have been made in behavioral and pharmacological treatments for addictions, moving treatment development to the next stage may require novel ways of approaching addictions, particularly ways based on new findings regarding the neurobiological underpinnings of addictions that also assimilate and incorporate relevant information from earlier approaches. In this review, we first briefly review theoretical and biological models of addiction and then describe existing behavioral and pharmacologic therapies for the addictions within this framework. We then propose new directions for treatment development and targets that are informed by recent evidence regarding the heterogeneity of addictions and the neurobiological contributions to these disorders.
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