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Related Concept Videos

Bacterial Signaling01:30

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
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Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
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Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Determinants of Bacterial Pathogenicity and Virulence

Pathogenic bacteria employ a variety of strategies to establish infections, including the secretion of extracellular enzymes that act as potent virulence factors. These enzymes facilitate bacterial colonization of host tissues and help evade immune surveillance. By targeting structural components of host tissues and interfering with immune mechanisms, these enzymes play a pivotal role in disease progression.Extracellular Enzymes Facilitating Tissue Invasion: Several bacterial pathogens secrete...
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Related Experiment Video

Updated: Jun 4, 2026

Introducing Shear Stress in the Study of Bacterial Adhesion
13:28

Introducing Shear Stress in the Study of Bacterial Adhesion

Published on: September 2, 2011

Bacterial adherence to suture materials.

Brendan D Masini1, Daniel J Stinner, Scott M Waterman

  • 1Department of Orthopaedics and Rehabilitation, Brooke Army Medical Center, Ft Sam Houston, Texas 78234, USA. Brendan.Masini@amedd.army.mil

Journal of Surgical Education
|February 23, 2011
PubMed
Summary
This summary is machine-generated.

Polyglycolic acid suture (Vicryl) showed the highest bacterial adherence, increasing infection risk. Avoid absorbable braided sutures in contaminated wounds. Antibiotic-impregnated versions may lose efficacy over time.

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Last Updated: Jun 4, 2026

Introducing Shear Stress in the Study of Bacterial Adhesion
13:28

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Published on: September 2, 2011

Biomimetic Materials to Characterize Bacteria-host Interactions
12:22

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Automated, High-Throughput Detection of Bacterial Adherence to Host Cells
07:21

Automated, High-Throughput Detection of Bacterial Adherence to Host Cells

Published on: September 17, 2021

Area of Science:

  • Surgical materials science
  • Microbiology
  • Infection control

Background:

  • Wound infections pose a significant challenge in medical practice.
  • Suture material choice, though operator-dependent, may influence wound infection rates.
  • Limited objective data exists to guide suture selection for infection prevention.

Purpose of the Study:

  • To evaluate and compare bacterial adherence to commonly used suture materials.
  • To provide objective data for guiding suture selection in wound closure.
  • To assess the role of suture material in the development of wound infections.

Main Methods:

  • A bioluminescent in vitro model was used to quantify bacterial adherence.
  • Eleven strands of various sutures (poliglecaprone, polypropylene, silk, polyglycolic acid, and antimicrobial polyglycolic acid) were tested.
  • Staphylococcus aureus engineered for bioluminescence was used to assess biofilm formation and residual bacteria.

Main Results:

  • Polyglycolic acid suture (Vicryl) exhibited the highest statistically significant bacterial adherence compared to all other tested materials.
  • No significant differences in bacterial adherence were found between polypropylene, silk, poliglecaprone, and antimicrobial polyglycolic acid sutures.
  • Antimicrobial polyglycolic acid suture showed similar adherence to other types but may degrade over time.

Conclusions:

  • Absorbable braided sutures, such as Vicryl, should be avoided in contaminated or high-risk wounds due to increased bacterial adherence.
  • Practitioners should consider suture material's bacterial adherence properties when closing wounds or managing infected wounds.
  • The efficacy of antibiotic-impregnated sutures may diminish over time, necessitating careful selection and monitoring.