Related Experiment Video
Updated: Jun 4, 2026
06:47
Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
Published on: September 27, 2017
[Allergic contact dermatitis caused by formaldehyde and formaldehyde releasers]
N Latorre1, J F Silvestre, A F Monteagudo
1Sección de Dermatología, Hospital General Universitario de Alicante, Alicante, Spain. nuria_latorre_martinez@hotmail.com
Actas Dermo-Sifiliograficas
|February 23, 2011
Summary
Formaldehyde and formaldehyde-releasing substances commonly cause allergic contact dermatitis. This review covers exposure sources, symptoms, and provides diagnostic and treatment guidelines for this widespread condition.
Area of Science:
- Allergenology
- Dermatology
- Toxicology
Context:
- Formaldehyde is a ubiquitous preservative in consumer and industrial products.
- Formaldehyde and its releasers are frequent causes of allergic contact dermatitis.
- This condition is often chronic due to pervasive exposure.
Purpose:
- To review sources of formaldehyde and formaldehyde releaser exposure.
- To describe clinical manifestations of formaldehyde-induced allergic contact dermatitis.
- To propose diagnostic and treatment guidelines for formaldehyde contact dermatitis.
Summary:
- This article examines the widespread use of formaldehyde and formaldehyde-releasing substances.
- It details their role in allergic contact dermatitis, including clinical presentations.
- The review also discusses current research and offers management strategies.
Impact:
- Provides a comprehensive overview for clinicians managing formaldehyde contact dermatitis.
- Highlights the challenges in avoiding common allergens.
- Aims to improve patient outcomes through updated diagnostic and treatment approaches.
Related Concept Videos
01:30Drug Toxicity: Allergic Reactions
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
01:30Allergic Reactions: Anaphylaxis
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
02:06Allergic Reactions
Overview
01:19Hypersensitivity Reactions: Immune-Complex Reactions
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
01:27Allergic Drug Reactions
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
01:29Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...