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Updated: Jun 4, 2026

Generation of Integration-free Induced Pluripotent Stem Cells from Human Peripheral Blood Mononuclear Cells Using Episomal Vectors
Published on: January 1, 2017
Generation of pluripotent cancer-initiating cells from transformed bone marrow-derived cells
Chunfang Liu1, Songtao Xu, Zhan Ma
1Department of Laboratory Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.
Abstract:
Our previous studies indicated that pluripotent cancer-initiating cells existed in chemical carcinogen-transformed mouse bone marrow-derived cells (BMDCs). In this report, we named them as bone marrow-derived pluripotent cancer-initiating (bmPCI) cells. The bmPCI cells showed properties of embryonal carcinoma (EC) cells/embryonic stem (ES) cells in morphology and gene expression, differentiated into multiple somatic tumor cells, generated oocyte-like cells and later developed into blastocyst-like structures in vitro while causing teratocarcinomas in vivo. These findings demonstrate that pluripotent cancer-initiating cells can originate from BMDCs. It provides an accessible in vitro model for copying the "embryonal rest" phenomenon from adult cells.
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