Related Experiment Video
Updated: Jun 4, 2026

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials
Published on: June 25, 2018
MMT, Npeoc-protected spermine, a valuable synthon for the solid phase synthesis of oligonucleotide oligospermine
Phanélie Perche1, Mitsuharu Kotera, Jean-Serge Remy
1Laboratoire de Chimie Génétique, UMR7199 CAMB, CNRS et Université de Strasbourg, Faculté de Pharmacie, 67401 Illkirch, France.
Abstract:
Solid phase spermine oligomerization via guanidine linkers was achieved using activated thiourea coupling reaction with primary amino group. Disymmetric spermine synthon was efficiently synthesised in eight steps from spermine. MMT group was used as coupling monitor and resulting oligomeric spermines were conjugated to oligonucleotides.
More Related Videos
Related Concept Videos
Preparation of 1° Amines: Gabriel Synthesis
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...
Biosynthesis of Nucleic Acids

