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Updated: Jun 4, 2026

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
Cytotoxic T cells - stroma interactions
Muhammad Zaeem Noman1, Houssem Benlalam, Meriem Hasmim
1Inserm, PR1 and IFR, laboratoire d’immunologie des tumeurs humaines : interaction effecteurs cytotoxiques-système tumoral, Institut Gustave-Roussy, Villejuif, France. noman@igr.fr
Abstract:
The tumor microenvironment is a complex system playing an important role in tumor development and progression. Besides tumor cells, the tumor microenvironment harbours a variety of host-derived cells, such as endothelial cells, fibroblasts, innate and adaptive immune cells, as well as extracellular matrix (ECM) fibers, cytokines, and other mediators. This review discusses the potential role of hypoxia and endothelial cells within tumor microenvironment and emphasizes their interaction with antigen specific killer cells.
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