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Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
Placental pathology in neonatal stroke
Jorina Elbers1, Sandra Viero, Daune MacGregor
1Division of Neonatology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Pediatrics
|February 23, 2011
Summary
Neonatal stroke may be linked to placental pathology. This study found placental lesions in 10 of 12 cases, suggesting a potential contributing factor to infant stroke.
Area of Science:
- Perinatal medicine
- Neurology
- Pathology
Background:
- Neonatal stroke is a growing concern with identified risk factors.
- The placenta's role in neonatal stroke is suspected but not well-described pathologically.
- This study addresses the gap in understanding placental contributions to neonatal stroke.
Purpose of the Study:
- To systematically evaluate prenatal, maternal, and neonatal risk factors for neonatal stroke.
- To describe placental pathology in infants diagnosed with neonatal stroke.
- To correlate placental findings with clinical presentation, risk factors, and outcomes.
Main Methods:
- Retrospective review of 12 neonatal stroke cases from the Canadian Pediatric Ischemic Stroke Registry (1992-2006).
- Analysis of clinical data including maternal, prenatal, and neonatal risk factors.
- Gross and microscopic examination and classification of placental pathology in available specimens.
Main Results:
- Ten of 12 neonates (83%) had placental lesions.
- Common placental lesions included thromboinflammatory processes (6 cases) and sudden catastrophic events (5 cases).
- Multiple risk factors (maternal, prenatal, neonatal) were identified in the majority of cases.
Conclusions:
- Placental pathology is frequently observed in neonates with stroke.
- Findings suggest placental lesions may contribute to the development of neonatal stroke.
- Further research with larger, controlled studies is needed to clarify the implications of specific placental lesions.
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