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Updated: Jun 4, 2026

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

Chemically modified solid state nanopores for high throughput nanoparticle separation.

Anmiv S Prabhu¹, Talukder Zaki N Jubery, Kevin J Freedman

¹School of Biomedical Engineering and Health Science, Drexel University, Philadelphia, PA 19104, USA.

Journal of Physics. Condensed Matter : an Institute of Physics Journal

|February 23, 2011

Summary

This summary is machine-generated.

This study demonstrates a solid-state nanopore platform for efficient nanoparticle separation. By controlling nanopore surface charge, researchers achieved selective separation of different-sized nanoparticles, paving the way for advanced nanosieving systems.

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Area of Science:

Nanotechnology
Biomolecular separation
Analytical chemistry

Background:

Nanoparticle separation is crucial for analytical and diagnostic techniques.
Existing methods face challenges in efficiency and selectivity.
Solid-state nanopores offer a promising platform for nanoscale separations.

Purpose of the Study:

To develop and validate a solid-state nanopore system for efficient nanoparticle separation.
To investigate the role of nanopore surface charge density in separation selectivity and throughput.
To demonstrate the separation of nanoparticles with different sizes using the developed system.

Main Methods:

Mathematical modeling using the multi-ion model to understand particle translocation through nanopores.
Fabrication of a single 150 nm pore in a silicon nitride membrane using focused-ion-beam milling.
Chemical modification of the nanopore membrane with (3-aminopropyl)triethoxysilane to alter surface charge density.
Experimental separation of 22 nm and 58 nm polystyrene nanoparticles.

Main Results:

Surface charge density was identified as a critical parameter for nanopore selectivity and separation throughput.
Successful chemical modification of the nanopore membrane was achieved.
Demonstrated selective separation of 22 nm and 58 nm polystyrene nanoparticles.
The system showed potential for scaling up to nanopore arrays.

Conclusions:

Solid-state nanopores provide an efficient platform for nanoparticle separation.
Surface charge modification is key to achieving selective separation.
This technology can be scaled for next-generation nanosieving applications.